We pride ourselves in having
self-diagnosed our infertility, but while FAM can point you a certain direction, it doesn't provide a diagnosis. We needed expert opinion on what kind of infertility we are facing so we visited a fertility specialist, who eventually informed us that from his initial observations it looks like
Polycystic Ovarian Syndrom (PCOS). The thing with PCOS is that it is a spectrum of fertility issues that may or may not have anything to do with ovarian cysts. In fact for a lot of women, a hormonal imbalance perhaps due to a malfunctioning thyroid can be diagnosed as PCOS, as would a pre-cancerous cyst. So we needed to find the specific infertility affecting us.
From FAM, we can see the interplay of three reproductive hormones:
estrogen (obviously),
luteinizing hormone (LH), and
progesterone. BBT charts show lower temps because estrogen rules pre-ovulation. The temps rise after ovulation because of progesterone. Ovulation tests work by detecting the presence of LH. But there is another important hormone is this interplay:
Follicle-Stimulating Hormone (FSH).
It is responsible for arbitrating follicle competition and nurturing an egg to
maturation in ovarian follicles, and for releasing the egg during a so-called "LH surge" (what we collectively call ovulation). By a process of elimination, FSH became the culprit that was later confirmed by labs (blood panels). Ultrasounds around the time of ovulation revealed a pattern of
anovulation (no mature follicles were observed 1-2 days before ovulation). So we moved from a general diagnosis of PCOS to a more specific "anovulation due to FSH deficiency". With that, two more questions arose: (1) what causes FSH deficiency? (2) How is this hormone imbalance treated?
The cause is not as easy to pin down because of the complexity of the endocrine system. We learned that a deficiency in some gland (say the thyroid or the pituitary glands) can affect the production of hormones elsewhere in the body, and this is what was likely happening in our case. The doctor thinks there is actually an estrogen imbalance that is affecting FSH. More specific blood panels and two possible causes emerge:
vitamin D deficiency and
insulin resistance. It is amazing how lifestyle and diet now tie into fertility, so we know treatment will not be singular.
The treatments start with
Letrozole (
as an alternative to Clomid) to help regulate estrogen and restore ovulation. Daily supplementation with vitamin D is recommended, and
Metformin is prescribed for insulin resistance, even as diabetes is
not diagnosed. We institute a low-sugar diet ("The Sugar Solution" is an excellent resource) and continue daily exercise. We also started seeing a doctor that specializes in PCOS treatment, who helped with the specification of said diet. We know the diet and exercise are working already just a couple of months in.
Even as we do infertility treatment, we are aware of the possibility that it may not work. After some heavy discussions, we decided that we would try any options (clinical or alternative) that are reasonably available, but would not do
surrogacy or IUIs and beyond. At that point, we would take a break and eventually turn to adoption. But we do what we can while we still can (insurance, etc).
It is emotionally draining and stressful to deal with such a diagnosis, the medications, the doctor visits, and the numerous clinical procedures you undergo. I applaud my dear wife for the courage and strength she has shown in this journey. As long as there is visibility into the condition (we know what is going on), great chances are that there is a specific treatment plan for it. If you have been here, I encourage you to do your research and understand the condition yourself so that you can contribute to the doctor's prognosis. You know yourself better than a doctor does, and many doctors appreciate informed patients and working as a team. It is not an easy journey and it requires persistence and diligence.
I should also say that no one treatment plan works for everyone precisely because infertility is variable in different people, even under the same diagnosis. Fertility is one of the few areas where treatment must be quite specific and exact for a given degree of diagnosis.